Safety Data

/Safety Data
Safety Data 2018-01-02T21:42:32+00:00

Arachidonic Acid Supplement Safety

ARASYN™ is an FDA GRAS Ingredient with abundant safety data behind it. Very few sports nutrition ingredients have undergone extensive safety studies, and fewer still the rigorous evaluations required for an FDA GRAS review.

FDA GRAS (Generally Recognized as Safe)

Our material has been granted SA GRAS status by the FDA for use in infant formula.

Lower Adult Dosage

The ARA GRAS notification for infant formula reports an estimated daily intake (EDI) of 27 mg/kg BW/day for preterm infants and 42 mg/kg BW/day for term infants. The maximum recommended adult daily supplemental dose for sports nutrition applications (1.5 g/d) equates to 25 mg/kg BW/day for a 60 kg adult; i.e., a lower intake than the GRASed EDI for preterm infant formula.

Supplementation Safety Studies

The supplementation of arachidonic acid by adults has been the subject of several extensive clinical evaluations in doses ranging from 700mg to 1.5 grams per day. In all cases (cited below) supplementation was shown to be safe, with no negative changes to cardiovascular, inflammatory, immune, or other health markers reported, nor any adverse effects noted.

Study Reference Dosage/Duration Main Outcome
Roberts et al. JISSN 2007 Nov 28;4:21 1,000 mg/day for 50 days No change to serum clinical safety markers. No adverse health effects.
Nelson et al. Lipids Apr;32(4):421-5 1,500 mg/day for 50 days No change to platelet aggregation values. No adverse health effects.
Nelson et al. Lipids Apr;32(4):427-33 1,500 mg/day for 50 days No change to lipids or lipoproteins. No adverse health effects.
Kelley et al. Lipids Feb;33(2):125-30 1,500 mg/day for 50 days No change to inflammatory or immune markers. No adverse health effects.
Thies et al. Lipids 36(11):1183-93 700 mg/day for 12 weeks No change to inflammatory cells or markers. No adverse health effects.
Kusumoto et al. Br. J Nutr. 98(3):626-35 838 mg/day for 6 weeks No change to platelet aggregation values. No adverse health effects.
Kakutani et al. Lipids HD 2011, 10:241 720 mg/day for 4 weeks No change to cardiovascular, inflammatory or allergic markers. No adverse health effects.

Baylor Exercise and Safety Review

Baylor University conducted an extensive evaluation on the health effects of ARASYN™ supplementation in healthy young men during a 50-day resistance training program. This was unique from most other studies which used sedentary (inactive) subjects. They also noticed no change in health markers, nor any side effects reported.

These results suggest that AA supplementation during an extended period of resistance training is physiologically well-tolerated and does not alter whole blood, liver or kidney clinical safety markers.

Reduced Inflammatory Markers

The Baylor University study also noted that when 1,000 mg/day of ARASYN™ arachidonic acid was taken during resistance training, there was a significant reduction in resting levels of IL-6 after 25 days, which is a key marker of inflammation. This result suggests that exercising individuals may incur additional benefits with regard to the systemic inflammatory response when supplementing arachidonic acid. More research is needed to understand this potential effect.

Arachidonic acid effects on bench press strength (graph)

Side Effects

Many users report increased muscle soreness in the days after exercise while supplementing arachidonic acid, a phenomenon known as delayed onset muscle soreness (DOMS). This may be linked to the way this ingredient intensifies the physiological response to exercise in your muscles, which may involve localized inflammation and soreness. Because of this, the increased soreness may indicate greater anabolic stimulus, and thus would be more of an expected effect than a side effect. Maintaining proper hydration and a well-balanced high protein diet is recommended for enhancing results and minimizing muscle soreness.

Contraindications

ARASYN™ arachidonic acid should not be used by individuals with a history of inflammatory disease. Arachidonic acid can be converted to pro-inflammatory compounds in the body, and thus its supplementation under inflammatory conditions may exacerbate symptoms. Women that are pregnant or nursing, or anyone taking medications, or suffering from any disease, should seek approval from a physician before taking arachidonic acid supplements.