Our material has been granted SA GRAS status by the FDA for use in infant formula.
The ARA GRAS notification for infant formula reports an estimated daily intake (EDI) of 27 mg/kg BW/day for preterm infants and 42 mg/kg BW/day for term infants. The maximum recommended adult daily supplemental dose for sports nutrition applications (1.5 g/d) equates to 25 mg/kg BW/day for a 60 kg adult; i.e., a lower intake than the GRASed EDI for preterm infant formula.
The supplementation of arachidonic acid by adults has been the subject of several extensive clinical evaluations in doses ranging from 700mg to 1.5 grams per day. In all cases (cited below) supplementation was shown to be safe, with no negative changes to cardiovascular, inflammatory, immune, or other health markers reported, nor any adverse effects noted.